Current

Principal at Craig Binnie Consulting
Associate at Alba Biologics Group

Past

Director, Drug Development at Trillium Therapeutics, Inc.

Director, Regulatory Affairs and Manufacturing at Transition Therapeutics, Inc

Director, Clinical Product Development at YM BioSciences, Inc

Project Manager, Biotechnology at YM BioSciences, Inc

Group Leader, Biology at Cangene Corporation

Project Leader, Research/Molecular Biology at Cangene Corporation

Senior Scientist at Pfizer Ltd

Publications


1. Coote, J.G. & Binnie, C. (1981). Association between DNA replication and interference by bromodeoxyuridine with sporulation in B.subtilis. In Sporulation and Germination (Levinson, Sonenshein & Tipper, Eds.). American Society for Microbiology, Washington, D.C., pp. 157-162.

2. Binnie, C. & Coote, J.G. (1983). Density gradient analysis of DNA replicated during B.subtilis sporulation. J. Bacteriol. 156, 466-470.

3. Coote, J.G. & Binnie, C. (1986). Tolerance to bromodeoxyuridine in a thymidine-requiring strain of Bacillus subtilis. J. Gen. Microbiol. 132, 481-492.

4. Binnie, C. & Coote, J.G. (1986). Inhibition of sporulation in Bacillus subtilis by bromodeoxyuridine and the effect on DNA replication. J. Gen. Microbiol. 132, 493-502.

5. Binnie, C., Lampe, M. & Losick, R. (1986). Gene encoding the sigma-37 species of RNA polymerase sigma factor from Bacillus subtilis. Proc. Natl. Acad. Sci. USA 83, 5943-5947.

6. Lampe, M., Igo, M., Schafer, W., Binnie, C., Losick, R., Ray, C. & Moran, C. (1987). Studies on the structural gene for sigma-37, a secondary RNA polymerase sigma factor in Bacillus subtilis. In RNA polymerase and the regulation of transcription (Reznikoff et al., Eds.) Elsevier Science Publishing Co., pp 177-183.

7. Lampe, M., Binnie, C., Schmidt, R. & Losick, R. (1988). Cloned gene encoding the delta subunit of Bacillus subtilis RNA polymerase. Gene 67, 13-19.

8. Binnie, C., Warren, M. & Butler, M.J. (1989). Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis. J. Bacteriol. 171, 887-895.

9. Binnie, C. (1990). The use of synthetic oligonucleotides as hybridisation probes. In Advances in Gene Technology (P.J. Greenaway, Ed.). JAI Press, London. Vol. 1., pp. 135-154. 10. Butler, M.J., Binnie, C., Hunter, I.S., Sugden, D.A. & Warren, M. (1990). Genetic manipulation of the oxytetracycline biosynthetic pathway genes. Dev. Ind. Microbiol. 31, 41-50. 11. McDowall, K.J., Doyle, D., Butler, M.J., Binnie, C., Warren, M. & Hunter, I.S. (1991). Molecular genetics of oxytetracycline production by Streptomyces rimosus. In Genetics and Product Formation in Streptomyces (Noack, Krugel & Baumberg, Eds.) Plenum Press pp. 105-116.

12. Binnie, C. (1991). Designing the optimal oligo. Trends in Biotechnol. 9, 145-146.

13. Butler, M.J., Aphale, J.S., Binnie, C., DiZonno, M.A., Krygsman, P., Soltes, G.A., Walczyk, E. & Malek, L.T. (1994). The aminopeptidase N-encoding pepN gene of Streptomyces lividans 66. Gene 141, 115-119.

14. Butler, M.J., Binnie, C., DiZonno, M.A., Krygsman, P., Soltes, G.A., Soostmeyer, G., Walczyk,E. & Malek, L.T. (1995). Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66. Appl. Environ. Microbiol. 61, 3145-3150.

15. Binnie, C., Butler, M.J., Aphale, J.S., Bourgault, R., DiZonno, M.A., Krygsman, P., Liao, L., Walczyk, E. & Malek, L.T. (1995). Isolation and characterization of two genes encoding proteases associated with the mycelium of Streptomyces lividans 66. J. Bacteriol. 177, 6033-6040.

16. Binnie, C., Liao, L., Walczyk, E. & Malek, L.T. (1996). Isolation and characterization of a gene encoding a chymotrypsin-like serine protease from Streptomyces lividans 66. Can.J.Microbiol. 42, 284-288.

17. Butler, M.J., Aphale, J.S., Binnie, C., DiZonno, M.A., Krygsman, P., Soltes, G.A., Walczyk, E. & Malek, L.T. (1996). Cloning and analysis of a gene from Streptomyces lividans 66 encoding a novel secreted protease exhibiting homology to Subtilisin BPN'. Appl. Microbiol. Biotech. 45, 141-147.

18. Binnie, C., Cossar, J.C. & Stewart, D.I.H. (1997) Heterologous biopharmaceutical protein expression in Streptomyces. Trends in Biotechnol. 15, 315-320.

Binnie, C., Jenish, D., Cossar, D., Szabo, A., Trudeau, D., Krygsman, P., Malek, L. T. & Stewart, D. I. H. (1997) Expression and purification of soluble human erythropoietin receptor made in Streptomyces lividans 66. Protein Exp. Purif. 11, 271-278.

20. Stiernholm, N., Thompson, S., Binnie, C. & Keane, P. (2005) Methods and Formulations for Testosterone Suppression. PCT application no. PCT / CA2005